Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models

Minkyung Kang #, Jihye Choi #, Jeongho Han, Toshiyuki Araki, Soo-Whee Kim, Hyun-Hee Ryu, Min-Gyun Kim, Seoyeon Kim, Hanbyul Jang, Sun Yong Kim, Kyoung-Doo Hwang, Soobin Kim, Myeongjong Yoo, Jaegeon Lee, Kitae Kim, Pojeong Park, Ja Eun Choi, Dae Hee Han, Yujin Kim, Jeongyeon Kim, Sunghoe Chang, Bong-Kiun Kaang, Jung Min Ko, Keun-Ah Cheon, Joon-Yong An, Sang Jeong Kim, Hyungju Park, Benjamin G Neel, Chul Hoon Kim *, Yong-Seok Lee *

J Clin Invest. 2025 Feb 18:e176631.

Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors

Seung Ha Kim #, Jaegeon Lee #, Mirae Jang, Seung-Eon Roh, Soobin Kim, Ji Hwan Lee, Jewoo Seo, Jinhee Baek, Jae Yoon Hwang, In Seon Baek, Yong-Seok Lee, Eiji Shigetomi, C Justin Lee, Schuichi Koizumi, Sun Kwang Kim *, Sang Jeong Kim *

Nat Neurosci. 2025 Feb;28(2):336-345. Epub 2025 Jan 2.

2024

Neurobiological mechanisms of social recognition memory

Gaeun Park & Yong-Seok Lee

Neuroscience and Biobehavioral Psychology, ELSEVIER, 2024

Activity in the dorsal hippocampus-mPFC circuit modulates stress-coping strategies during inescapable stress

Sang Ho Yoon, Woo Seok Song, Geehoon Chung, Sang Jeong Kim, Myoung-Hwan Kim

Exp Mol Med. 2024 Sep;56(9):1921-1935. Epub 2024 Sep 2.

Dual effects of TGF-β inhibitor in ALS - inhibit contracture and neurodegeneration

Do-Yeon Lee, Young Nam Kwon, Kwangkook Lee, Sang Jeong Kim, Jung-Joon Sung

J Neurochem. 2024 Sep;168(9):2495-2514. Epub 2024 Mar 21.

Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway

Kyeong-No Yoon, Sun Yong Kim, Jungeun Ji, Yidan Cui, Qing‐Ling Quan, Gunhyuk Park, Jang-Hee Oh, Ji Su Lee, Joon-Yong An, Jin Ho Chung *, Yong-Seok Lee * & Dong Hun Lee *

Exp Mol Med. 2024 Jun;56(6):1401-1411. Epub 2024 Jun 3.

Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

Jewoo Seo, Seung Ha Kim, Jaegeon Lee, Min Seok Kim, Yong-Seok Lee, Sang Jeong Kim

eLife. 2024 May 23.

SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD

Sanghyeon Lee, Jungho Kim, Hyun-Hee Ryu, Hanbyul Jang, DoEun Lee, Seungha Lee, Jae-man Song, Yong-Seok Lee & Young Ho Suh 

Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2316819121. Epub 2024 Apr 24.

Localization of hyperpolarization-activated cyclic nucleotide-gated channels in the vertebrate retinas across species and their physiological roles

Daniel Kim #, Hyeonhee Roh #, Hyung-Min Lee, Sang Jeong Kim, Maesoon Im

Front Neuroanat. 2024 Mar 18:18:1385932. eCollection 2024.

Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features

Myeong Seong Bak #, Haney Park #, Heera Yoon, Geehoon Chung, Hyunjin Shin, Soonho Shin, Tai Wan Kim, Kyungjoon Lee, U Valentin Nägerl, Sang Jeong Kim, Sun Kwang Kim

Front Mol Neurosci. 2024 Feb 21;17:1356453.

Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory

Jaegeon Lee, Seung Ha Kim, Dong Cheol Jang, Mirae Jang, Myeong Seong Bak, Hyun Geun Shim, Yong-Seok Lee & Sang Jeong Kim

Mol Psychiatry. 2024 Feb;29(2):247-256.

2023

α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis

Dayana Pérez-Acuña, Soo Jean Shin, Ka Hyun Rhee, Sang Jeong Kim, Seung-Jae Lee

Mol Brain. 2023 Oct 17;16(1):72.

Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder

Gaeun Park #, Wooyoung Eric Jang #, Seoyeon Kim #, Edson Luck Gonzales, Jungeun Ji, Seunghwan Choi, Yujin Kim, Ji Hwan Park, Hazara Begum Mohammad, Geul Bang, Minkyung Kang, Soobin Kim, Se Jin Jeon, Jin Young Kim, Kwang Pyo Kim, Chan Young Shin *, Joon-Yong An *, Min-Sik Kim * & Yong-Seok Lee *

Exp Mol Med. 2023 Aug;55(8):1783-1794.

Dynamic alteration of intrinsic properties of the cerebellar Purkinje cell during the motor memory consolidation

Dong Cheol Jang, Geehoon Chung, Sun Kwang Kim, Sang Jeong Kim

Mol Brain. 2023 Jul 10;16(1):58.

Effect of a differential training paradigm with varying frequencies and amplitudes on adaptation of vestibulo-ocular reflex in mice

Ngoc Chien Pham, Yong Gyu Kim, Sang Jeong Kim, Chang-Hee Kim

Exp Brain Res. 2023 May;241(5):1299-1308.

mGluR1 Regulates the Interspike Interval Threshold for Dendritic Ca2+ Transients in the Cerebellar Purkinje Cells

Dong Cheol Jang, Changhyeon Ryu, Geehoon Chung, Sun Kwang Kim, Sang Jeong Kim

Exp Neurobiol. 2023 Apr 30;32(2):83-90. 

Cerebellar nuclei neurons projecting to the lateral parabrachial nucleus modulate classical fear conditioning

Kyoung-Doo Hwang, Jinhee Baek, Hyun-Hee Ryu, Jaegeon Lee, Hyun Geun Shim, Sun Yong Kim, Sang Jeong Kim & Yong-Seok Lee

Cell Rep. 2023 Apr 25;42(4):112291.

Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster

Sung Yeon Park, Jieun Seo, Seulbee Lee, Joohyung Kim, Sang Jeong Kim, Seungbok Lee, Yang-Sook Chun

Genes Dis. 2023 Mar 24;10(6):2248-2251.

Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice

Young Hee Lee #, Yu-Been Kim #, Kyu Sik Kim #, Mirae Jang #, Ha Young Song, Sang-Ho Jung, Dong-Soo Ha, Joon Seok Park, Jaegeon Lee, Kyung Min Kim, Deok-Hyeon Cheon, Inhyeok Baek, Min-Gi Shin, Eun Jeong Lee, Sang Jeong Kim *, Hyung Jin Choi *

Nat Commun. 2023 Mar 17;14(1):1486.

Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis

Wooyoung Eric Jang #, Ji Hwan Park #, Gaeun Park, Geul Bang, Chan Hyun Na, Jin Young Kim, Kwang-Youl Kim, Kwang Pyo Kim, Chan Young Shin, Joon-Yong An, Yong-Seok Lee & Min-Sik Kim

Mol Psychiatry. 2023 Feb;28(2):810-821.

Serum C3 complement levels predict prognosis and monitor disease activity in Guillain-Barré syndrome

Young Gi Min, Woohee Ju, Jae-Woo Seo, Ye-Eun Ha, Jae-Jun Ban, Young Nam Kwon, Han-Yeong Jeong, Je-Young Shin, Sung-Min Kim, Yoon-Ho Hong, Sang-Jeong Kim, Jung-Joon Sung

J Neurol Sci. 2023 Jan 15:444:120512.

2022

Cerebellum as a kernel machine: A novel perspective on expansion recoding in granule cell layer

Hyojin Bae, Sa-Yoon Park, Sang Jeong Kim *, Chang-Eop Kim *

Front Comput Neurosci. 2022 Dec 21:16:1062392.

Synaptic Remodeling of the Auditory Cortex Following Bilateral Blindness: Evidence of Cross-modal Plasticity

Jae Joon Han #, Tae-Soo Noh #, Myung-Whan Suh, Seung Ha Kim, Doo Hee Kim, Sang Jeong Kim *, Seung Ha Oh *

Exp Neurobiol. 2022 Oct 31;31(5):299-306.

Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex

Seunghui Woo, Yoo Rim Kim, Myeong Seong Bak, Geehoon Chung, Sang Jeong Kim *, Sun Kwang Kim *

Exp Neurobiol. 2022 Oct 31;31(5):324-331.

Development of a spontaneous pain indicator based on brain cellular calcium using deep learning

Heera Yoon #, Myeong Seong Bak #, Seung Ha Kim, Ji Hwan Lee, Geehoon Chung, Sang Jeong Kim *, Sun Kwang Kim *

Exp Mol Med. 2022 Aug;54(8):1179-1187.

Adaptation of Optokinetic Reflex by Training with Different Frequency and Amplitude

Ngoc Chien Pham, Yong Gyu Kim, Sang Jeong Kim, Chang-Hee Kim

J Integr Neurosci. 2022 Jul 22;21(5):131.

Metabotropic Glutamate Receptor 5 in the Dysgranular Zone of Primary Somatosensory Cortex Mediates Neuropathic Pain in Rats

Geehoon Chung, Yeong-Chan Yun, Chae Young Kim, Sun Kwang Kim, Sang Jeong Kim

Biomedicines. 2022 Jul 7;10(7):1633.

Simultaneous cellular imaging, electrical recording and stimulation of hippocampal activity in freely behaving mice

Chae Young Kim, Sang Jeong Kim * & Fabian Koolsterman *

Exp Neurobiol. 2022 Jun 30;31(3):208-220.

Adaptation of vestibulo-ocular and optokinetic reflexes after massed and spaced vestibulo-ocular motor learning

Ngoc Chien Pham, Yong Gyu Kim, Sang Jeong Kim, Chang-Hee Kim

Behav Brain Res. 2022 May 24:426:113837.

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD

Thomas M Sanderson, Liam T Ralph, Mascia Amici, Ai Na Ng, Bong-Kiun Kaang, Min Zhuo, Sang Jeong Kim, John Georgiou, Graham L Collingridge

Front Synaptic Neurosci. 2022 May 9:14:857675.

Novel measures of Morris water maze performance that use vector field maps to assess accuracy, uncertainty, and intention of navigational searches

Prabod Kumar Meenakshi, Dhruv Mehrotra, N. Nruthyathi, Daniel Almeida-Filho, Yong Seok Lee, Alcino Silva, J. Balaji

Hippocampus. 2022 Apr;32(4):264-285.

Cerebellar Circuits for Classical Fear Conditioning

Kyoung-Doo Hwang, Sang Jeong Kim & Yong-Seok Lee

Front Cell Neurosci. 2022 Mar 30:16:836948.

Altered synaptic connections and inhibitory network of the primary somatosensory cortex in chronic pain

Yoo Rim Kim, Sang Jeong Kim

Korean J Physiol Pharmacol. 2022 Mar 1;26(2):69-75.

Gradual decorrelation of CA3 ensembles associated with contextual discrimination learning is impaired by Kv1.2 insufficiency

Kisang Eom, Hyoung Ro Lee, Jung Ho Hyun, Hyunhoe An, Yong Seok Lee, Won Kyung Ho & Suk Ho Lee

Hippocampus. 2022 Mar;32(3):193-216.

Dysfunction of NMDA receptors in neuronal models of an autism spectrum disorder patient with a DSCAM mutation and in Dscam-knockout mice

Chae Seok Lim #, Min Jung Kim #, Ja Eun Choi #, Md Ariful Islam, You Kyung Lee, Yinyi Xiong, Kyu Won Shim, Jung eun Yang, Ro Un Lee, Jiah Lee, Pojeong Park, Ji Hye Kwak, Hyunhyo Seo, Chul Hoon Kim, Jae Hyung Lee, Yong Seok Lee, Su Kyeong Hwang, Kyungmin Lee *, Jin A. Lee * & Bong Kiun Kaang *

Mol Psychiatry. 2021 Dec;26(12):7538-7549.

Intramolecular disulfide bonds for biogenesis of calhm1 ion channel are dispensable for voltage-dependent activation

Jae Won Kwon, Young Keul Jeon, Jinsung Kim, Sang Jeong Kim & Sung Joon Kim

Mol Cells. 2021 Oct 31;44(10):758-769.

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

Eunee Lee #, Seungjoon Lee #, Jae Jin Shin #, Woochul Choi #, Changuk Chung, Suho Lee, Jihye Kim, Seungmin Ha, Ryunhee Kim, Taesun Yoo, Ye-Eun Yoo, Jisoo Kim, Young Woo Noh, Issac Rhim, Soo Yeon Lee, Woohyun Kim, Taekyung Lee, Hyogeun Shin, Il-Joo Cho, Karl Deisseroth, Sang Jeong Kim, Joo Min Park *, Min Whan Jung *, Se-Bum Paik * & Eunjoon Kim *

Nat Commun. 2021 Aug 25;12(1):5116.

Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice

Yong Gyu Kim #, Myeong Seong Bak #, Ahbin Kim #, Yujin Kim, Yun-Cheol Chae, Ye Lee Kim, Yang-Sook Chun, Joon-Yong An, Sang-Beom Seo, Sang Jeong Kim * & Yong-Seok Lee *

Mol Brain. 2021 Jul 3;14(1):106.

Minhee Analysis Package: an integrated software package for detection and management of spontaneous synaptic events

Yong Gyu Kim, Jae Jin Shin & Sang Jeong Kim

Mol Brain 14, 138 (2021).

Multi-Layer Nanofibrous PCL Scaffold-Based Colon Cancer Cell Cultures to Mimic Hypoxic Tumor Microenvironment for Bioassay

Eun-Taex Oh, Ha Gyeong Kim, Min-Ho Choi, Jae-Seon Lee, Sang Jeong Kim, Jong-Young Kwak & Heon Joo Park

Cancers 2021, 13(14), 3550

Chronic ultraviolet irradiation to the skin dysregulates adrenal medulla and dopamine metabolism in vivo

Hye Sun Lim, Kyeong No Yoon, Jin Ho Chung, Yong Seok Lee, Dong Hun Lee, Gunhyuk Park

Antioxidants, 10(6), [920].

Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice

Gaeun Park #, Changhyeon Ryu #, Soobin Kim, Se Jin Jeong, Ja Wook Koo, Yong-Seok Lee * & Sang Jeong Kim *

Cell Rep. 2021 May 11;35(6):109104.

Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling

Hye Young Shin, Kyung-Seok Han, Hyung Woo Park, Yun Hwa Hong, Yona Kim, Hyo Eun Moon, Kwang Woo Park, Hye Ran Park, C. Justin Lee, Kiyoung Lee, Sang Jeong Kim, Man Seung Heo, Sung-Hye Park, Dong Gyu Kim & Sun Ha Paek

Exp Neurobiol 2021; 30(2): 120-143

Lessons From Deep Neural Networks for Studying the Coding Principles of Biological Neural Networks

Hyojin Bae, Sang Jeong Kim & Chang Eop Kim

Frontiers in Systems Neuroscience, 14, [615129].

Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel

Young Keul Jeon, Si Won Choi, Jae Won Kwon, Joohan Woo, Seong Woo Choi, Sang Jeong Kim & Sung Joon Kim

Biochemical and Biophysical Research Communications, 534, 590-596.

Association between ARID2 and RAS-MAPK pathway in intellectual disability and short stature

Eungu Kang, Minji Kang, Younghee Ju, Sang Joon Lee, Yong Seok Lee, Dong Cheol Woo, Young Hoon Sung, In Jeoung Baek, Woo Hyun Shim, Woo Chan Son, In Hee Choi, Eul Ju Seo, Han Wook Yoo, Yong Mahn Han & Beom Hee Lee

Journal of Medical Genetics, 58(11), 767-777.

Ablation of STAT3 in purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

Jeong Kyu Han, Sun Ho Kwon, Yong Gyu Kim, Jaeyong Choi, Jong Il Kim, Yong Seok Lee, Sang Kyu Ye & Sang Jeong Kim

eLife, 10, 1-23. [e63291].

Autophagy pathway upregulation in a human iPSC-derived neuronal model of Cohen syndrome with VPS13B missense mutations

You-Kyung Lee, Soo-Kyeong Lee, Suin Choi, Yang Hoon Huh, Ji-Hye Kwak, Yong-Seok Lee, Deok-Jin Jang, Jae-Hyung Lee, Kyungmin Lee, Bong-Kiun Kaang, Chae-Seok Lim & Jin-A Lee

Molecular brain 13.1 (2020): 1-4.

Cohen Syndrome Patient iPSC-Derived Neurospheres and Forebrain-Like Glutamatergic Neurons Reveal Reduced Proliferation of Neural Progenitor Cells and Altered Expression of Synapse Genes

You-Kyung Lee ,Su-Kyeong Hwang, Soo-Kyung Lee, Jung-eun Yang, Ji-Hye Kwak, Hyunhyo Seo, Hyunjun Ahn, Yong-Seok Lee, Janghwan Kim, Chae-Seok Lim, Bong-Kiun Kaang, Jae-Hyung Lee, Jin-A Lee and Kyungmin Lee

Journal of clinical medicine 9.6 (2020): 1886.

Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder

Yong-Seok Lee, Nam-Kyung Yu, Jeewan Chun, Jung-eun Yang, Chae-Seok Lim, Hyopil Kim, Gaeun Park, Jin-A Lee, Kyungmin Lee, Bong-Kiun Kaang & Jae-Hyung Lee

Molecular brain (2020)

Intrinsic Plasticity of Cerebellar Purkinje Cells Contributes to Motor Memory Consolidation

Dong Cheol Jang, Hyun Geun Shim, and Sang Jeong Kim

The Journal of Neuroscience. 40(21):4145–4157 (2020)

Quantitative Proteomics Reveals Distinct Molecular Signatures of Different Cerebellum-Dependent Learning Paradigms

Yong Gyu Kim, Jongmin Woo, Joonho Park, Sooyong Kim, Yong-Seok Lee, Youngsoo Kim, Sang Jeong Kim

J Proteome Res. 1;19(5):2011-2025 (2020)

Differential Effects of Inferior Olive Lesion on Vestibulo-ocular and Optokinetic Motor Learning

Ngoc Chien Phama , Yong Gyu Kim, Sang Jeong Kim and Chang-Hee Kim

Neuroreport. 31(1):9-16 (2020)

Reduced chronic restraint stress in mice overexpressing hyperactive proteasomes in the forebrain

Ji Hyeon Kim, Ahbin Kim, Yejin Yun, Seoyoung Park, Jung Hoon Lee, Yong-Seok Lee, Min Jae Lee

Molecular Brain 13.4 (2020)

Connecting the dots between SHP2 and glutamate receptors

Hyun-Hee Ryu, Sun Yong Kim, and, Yong-Seok Lee

The Korean Journal of Physiology & Pharmacology 24.2 (2020)

Persistent Activity of Metabotropic Glutamate Receptor 5 in the Periaqueductal Gray Constrains Emergence of Chronic Neuropathic Pain.

Geehoon Chung, Hyun Geun Shim, Chae Young Kim, Hyun-Hee Ryu, Dong Cheol Jang, Seung Ha Kim, Jaegeon Lee, Chang-Eop Kim, Yu Kyeong Kim, Yong-Seok Lee, Jun Kim, Sun Kwang Kim, Paul F Worley, Sang Jeong Kim

Current Biology 2020Sep 15; S0960-9822(20)31339-7

Direct translation of climbing fiber burst-mediated sensory coding into post-synaptic Purkinje cell dendritic calcium.

Seung-Eon Roh, Seung Ha Kim, Changhyeon Ryu, Chang-Eop Kim, Yong Gyu Kim, Paul F Worley, Sun Kwang Kim, Sang Jeong Kim

Elife 2020 Sep 28;9:e61593

Decreased intrinsic excitability of cerebellar Purkinje cells following optokinetic learning in mice.

Yong Gyu Kim, Sang Jeong Kim

Molecular Brain.2020 Oct 7;13(1):136

Neuron type-specific expression of a mutant KRAS impairs hippocampal-dependent learning and memory.

Hyun-Hee Ryu, Minkyung Kang, Kyoung-Doo Hwang, Han Byul Jang, Sang Jeong Kim, Yong-Seok Lee

Scientific Reports. 2020 Oct 20;10(1):17730