Prof. Yong-Seok Lee, Ph.D

We are investigating the molecular and cellular mechanism underlying Learning, Memory, and related Disorders such as learning disability, autism, and dementia. 

1. Mechanism of learning disability associated with RASopathies (Noonan syndrome). 

RASopathy is a group of developmental disorders caused by the mutations of the genes in Ras-Erk signaling. RASopathy includes Noonan syndrome, NF1, CFC syndrome, Leopard syndrome etc. Cognitive deficits are commonly associated with RASopathy, but the mechanism is largely unknown. We are using mouse models of RASopathy to study the mechanism and treatment for cognitive problems associated with RASopathy. 

2. Molecular & network mechanism of memory enhancement in mice. 

We are searching for the molecular, cellular and network mechanism of memory enhancement that can be used to develop novel treatments for memory disorders including neurodevelopmental and neurodegenerative disorders.

We are using diverse techniques including

1. Molecular Biology

2. Mouse Behavior (& optogenetics)

3. Electrophysiology (field recording)

4. Mutant mice